Data driven identification of tip-sample interaction in atomic force microscopy
Abhilash Chandrashekar  1@  , Pierpaolo Belardinelli  2@  , Miguel Bessa  3@  , Urs Staufer  1@  , Farbod Alijani  4, *@  
1 : TU Delft
Faculty 3mE, Department of Precision and Microsystems Engineering, Mekelweg 2, 2628 CD Delft -  Netherlands
2 : DICEA, Polytechnic University of Marche
DICEA, Polytechnic University of Marche, -  Italy
3 : TU Delft
TU Delft -  Netherlands
4 : TU Delft
Department of Precision and Microsystems Engineering, Delft University of Technology, Mekelweg 2, 2628 CD, Delft -  Netherlands
* : Corresponding author

Dynamic AFM is transitioning from a high-resolution imaging tool to a nanomechanical probe that can perform precise quantification of matter in fields as varied as microbiology, molecular metrology, and material science. To date, this has been achieved by estimating the nanoscale forces that exist between the probe and the sample, using empirical models that are merely approximations of the true probe-sample interaction physics. Here, we go beyond such approximations by making use of the recent advances in datascience and machine learning to distil nonlinear governing equations of dynamic AFM, and thus predict tip-sample forces directly from experimental raw deflection data. Our data-driven algorithm obtains physics-based models from experiments and is able to estimate time-resolved nanoscale interactions with sub-microsecond resolution.


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